Figure 6. Comparison of multicompartment simulations in mouse and frog fibers. In both fiber types, the simulated SR release waveform has the functional form of Eq. 3; the parameter values are similar to those in the corresponding parts of Fig. 5 except that the total release amounts and values of τ1 and τ2 are 349 µM, 1.3 ms, and 0.5 ms (A); and 345 µM, 1.75 ms, and 0.7 ms, respectively (B). With these values, the peak of each simulated ΔfCaD waveform matches that of the corresponding measurement. The FDHM of the simulated ΔfCaD waveform is 5.1 ms in A and 6.7 ms in B. The peak value, time of peak, and FDHM of the release waveforms are 205 µM/ms, 2.8 ms, and 1.6 ms (A); and 144 µM/ms, 2.9 ms, and 2.2 ms, respectively (B).
Figure 6.

Comparison of multicompartment simulations in mouse and frog fibers. In both fiber types, the simulated SR release waveform has the functional form of Eq. 3; the parameter values are similar to those in the corresponding parts of Fig. 5 except that the total release amounts and values of τ1 and τ2 are 349 µM, 1.3 ms, and 0.5 ms (A); and 345 µM, 1.75 ms, and 0.7 ms, respectively (B). With these values, the peak of each simulated ΔfCaD waveform matches that of the corresponding measurement. The FDHM of the simulated ΔfCaD waveform is 5.1 ms in A and 6.7 ms in B. The peak value, time of peak, and FDHM of the release waveforms are 205 µM/ms, 2.8 ms, and 1.6 ms (A); and 144 µM/ms, 2.9 ms, and 2.2 ms, respectively (B).

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