![Figure 3. Predictions of the well-mixed model. (A) Schematic of well-mixed model showing neuronal K+ release into ECS, and astrocytic uptake of K+ and water causing ECS shrinkage. (B) Time course of ECS potassium concentration ([K+]e) and volume (de), astrocyte membrane potential (ψ), and astrocyte K+ and water flux (JKa, JVa) after neuronal excitation causing [K+]e increase from 5 to 10 mM. Parameters: Pf = 0.04 cm/s, JKno = 10−8 mol/cm2/s, Δtn = 0.1 s, da = 10 µm, de = 2 µm, with the indicated PK. (C) Computations as in B for PK = 1.2 × 10−5 cm/s with the indicated Pf. (D) Computations as in B for PK = 1.2 × 10−5 cm/s, with the indicated de. JKno was adjusted to increase [K+]e from 5 to 10 mM. (E) Effect of magnitude of neuroexcitation. Computations as in B, with PK = 1.5 × 10−5 cm/s and JKno = 5 × 10−8 mol/cm2/s, with the indicated Pf. (F) The effect of duration of neuroexcitation. Computations as in B, with PK = 1.3 × 10−5 cm/s, JKno = 8 × 10−10 mol/cm2/s, and Δtn = 10 s, with the indicated Pf.](https://cdn.rupress.org/rup/content_public/journal/jgp/141/1/10.1085_jgp.201210883/4/jgp_201210883_fig3.jpeg?Expires=1767655238&Signature=tzKJK7pzy5xOqYGXKBAygdJqGm1Fn2kskWFu8TysDCXssm7-f9Wyhx9UQBfvyEFloxl9kEw-EaUaH7hon8QfEHWADXVGkfLpF~8BqeE6KCrT3sIl6RMOV32VEUgQ0cD-6LkmOMpMVYu614s2zAEPMFPn3Tw5MX186q6iZOOVO6tbLcLHB2GlbOQAzwosena00oPFr8vTY3NmTWAgvRFBnGveat8022wSt963GVt1qF6oq9C--rPpzy2v0ZQ~eODcgekYjSje7ELsom-6nS~SukrpbceUphdM4wVfkCXnbpg1X~EFbavKuSs7GSQjH8p93ZQjTuLdrjIZjcPZk80irw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Predictions of the well-mixed model. (A) Schematic of well-mixed model showing neuronal K+ release into ECS, and astrocytic uptake of K+ and water causing ECS shrinkage. (B) Time course of ECS potassium concentration ([K+]e) and volume (de), astrocyte membrane potential (ψ), and astrocyte K+ and water flux (JKa, JVa) after neuronal excitation causing [K+]e increase from 5 to 10 mM. Parameters: Pf = 0.04 cm/s, JKno = 10−8 mol/cm2/s, Δtn = 0.1 s, da = 10 µm, de = 2 µm, with the indicated PK. (C) Computations as in B for PK = 1.2 × 10−5 cm/s with the indicated Pf. (D) Computations as in B for PK = 1.2 × 10−5 cm/s, with the indicated de. JKno was adjusted to increase [K+]e from 5 to 10 mM. (E) Effect of magnitude of neuroexcitation. Computations as in B, with PK = 1.5 × 10−5 cm/s and JKno = 5 × 10−8 mol/cm2/s, with the indicated Pf. (F) The effect of duration of neuroexcitation. Computations as in B, with PK = 1.3 × 10−5 cm/s, JKno = 8 × 10−10 mol/cm2/s, and Δtn = 10 s, with the indicated Pf.
