Figure 1.
Figure 1. Dendrogram and basic architecture of channels of the cyclic nucleotide–regulated superfamily. (A) Phylogenetic tree depicting the evolutionary relationships of the KCNH, CNG, and HCN ion channel families, computed with Cobalt (Papadopoulos and Agarwala, 2007) and displayed with Dendroscope (Huson et al., 2007). (B) Schematic of the architecture of a single mEAG1 subunit, with the structure of the CNBHD shown in magenta (Marques-Carvalho et al., 2012) and the tyrosine and leucine of the intrinsic ligand shown in blue. Inset includes a close-up view of the tyrosine and leucine of the intrinsic ligand superimposed with cAMP (yellow) from the HCN2 structure (Zagotta et al., 2003). Superposition of the mEAG1 and mHCN2 structures was done through residues in the β roll.

Dendrogram and basic architecture of channels of the cyclic nucleotide–regulated superfamily. (A) Phylogenetic tree depicting the evolutionary relationships of the KCNH, CNG, and HCN ion channel families, computed with Cobalt (Papadopoulos and Agarwala, 2007) and displayed with Dendroscope (Huson et al., 2007). (B) Schematic of the architecture of a single mEAG1 subunit, with the structure of the CNBHD shown in magenta (Marques-Carvalho et al., 2012) and the tyrosine and leucine of the intrinsic ligand shown in blue. Inset includes a close-up view of the tyrosine and leucine of the intrinsic ligand superimposed with cAMP (yellow) from the HCN2 structure (Zagotta et al., 2003). Superposition of the mEAG1 and mHCN2 structures was done through residues in the β roll.

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