Figure 5.
![Figure 5. Receptor density can account for differences in calcium signaling and PIP2 depletion. Simulations from our kinetic model. Low receptor densities (1 per µm2) mimic eP2Y2, and high receptor densities (500 per µm2) mimic high-density M1Rs. (A) Simulated time courses of Fura-4F (top) and KCNQ2/3 current (bottom) responses to UTP acting on low receptor densities (red line) and Oxo-M acting on high receptor densities (black line). [Fura-4F] was 1 µM. (B) Simulated time courses of calcium (top) and PIP2 (bottom) concentration changes with low and high receptor densities. Fura-4F concentration was set at 0 µM.](https://cdn.rupress.org/rup/content_public/journal/jgp/141/5/10.1085_jgp.201210886/4/jgp_201210886_fig5.jpeg?Expires=1773474638&Signature=27L-HnT0xDZvbq6IugfDtUinItwt78D4921y1RVYddGWOShQVKFktwr-9cGY5QBf3rVS-312IQxvvrvVKtDP2NHLgeIEu-YAYyrSVfY7OCoozv9o4t4WjoAHlfUKUlBZul4PUX0U3uHqVKWLsWKzM7-js8K1WI5Kb~35dxzPrFPhlzH06IRKxnChGhlzXohhT5tnnR-isesn2lJGjt8qrDe8LG6Xry2T9stLgARdJzy9h67N49nYsgrLJCWtRUqYTjpVpzY2A2D6RIgqP6xuJeGSWVTi7VXLlHj8SmDkmPeKV9La-fgutIcCuzUX8zNA2XQjv00U089Xp~D51YR~SQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Receptor density can account for differences in calcium signaling and PIP2 depletion. Simulations from our kinetic model. Low receptor densities (1 per µm2) mimic eP2Y2, and high receptor densities (500 per µm2) mimic high-density M1Rs. (A) Simulated time courses of Fura-4F (top) and KCNQ2/3 current (bottom) responses to UTP acting on low receptor densities (red line) and Oxo-M acting on high receptor densities (black line). [Fura-4F] was 1 µM. (B) Simulated time courses of calcium (top) and PIP2 (bottom) concentration changes with low and high receptor densities. Fura-4F concentration was set at 0 µM.
