Figure 2.
Figure 2. Dose-dependent inhibition of Panx1 currents by BB FCF. The membrane potential was clamped at −60 mV, and brief +60-mV pulses were applied at a rate of 0.1 Hz to open Panx1 channels. (A) BB FCF attenuated the Panx1-mediated currents in a dose-dependent fashion. (B) Dose–response relationship of inhibition of membrane currents by BB FCF. Means ± SD (n = 4) are plotted. (C) Uninjected control oocytes subjected to the same pulse protocol exhibited small currents unaffected by 10 µM BB FCF and by 10 µM Fast Green FCF.

Dose-dependent inhibition of Panx1 currents by BB FCF. The membrane potential was clamped at −60 mV, and brief +60-mV pulses were applied at a rate of 0.1 Hz to open Panx1 channels. (A) BB FCF attenuated the Panx1-mediated currents in a dose-dependent fashion. (B) Dose–response relationship of inhibition of membrane currents by BB FCF. Means ± SD (n = 4) are plotted. (C) Uninjected control oocytes subjected to the same pulse protocol exhibited small currents unaffected by 10 µM BB FCF and by 10 µM Fast Green FCF.

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