Logarithmically binned latency histograms of IP₃R channels responding to changes in and ⁠. In each case, (⁠⁠, ⁠) are changed as indicated: (A) IP₃ activation: (2 µM, 0 µM) → (2 µM, 10 µM). (B) IP₃ deactivation: (2 µM, 10 µM) → (2 µM, 0 µM). (C) Ca²⁺ activation: (0 µM, 10 µM) → (2 µM, 10 µM). (D) Ca²⁺ deactivation: (2 µM, 10 µM) → (0 µM, 10 µM). (E) Ca²⁺ and IP₃ activation: (0 µM, 0 µM) → (2 µM, 10 µM). (F) Ca²⁺ and IP₃ deactivation: (2 µM, 10 µM) → (0 µM, 0 µM). (G) Ca²⁺ inhibition: (2 µM, 10 µM) → (300 µM, 10 µM). (H) Ca²⁺ inhibition recovery: (300 µM, 10 µM) → (2 µM, 10 µM). The experimental latency distributions given by the bars are taken from Mak et al. (2007). The solid and dotted lines, respectively, are from the CM when fit to the latency data alone and to the latency and time-series data simultaneously.