Figure 7.
Kinetic scheme describing the ligand-bound gating behavior (bursts). The shaded region in the scheme accounts for the state transitions seen within single-channel bursts. Here, the kinetic scheme represents RyR2 activity at high [Ca2+]cyt (Fig. 4 B, scheme 3) where the bursts are longer in duration and better resolved. The symbols and labels are the same as in Fig. 4 B.