Figure 10.
The recombinant Kv4.2–KChIP1-DPP10a ternary channel complex expressed in tsA-201 cells exhibits a hybrid inactivation phenotype. Currents were recorded under cell-attached patch-clamping conditions (Materials and methods). Details of A–F are as described in the Fig. 5 legend. For comparison, the red symbol in C indicates the time constant determined from the double-pulse protocol. The conditioning pulse in D activated 15% of the peak conductance. The solid red line in E represents the following empirical best-fit sum of exponential terms: I/I0 = .5 − .52(1 − exp(−t/10))^1.4 + .5*exp(−t/120).
