Predictions of IKV records from an osmotically treated fiber by a two-channel model. (A) Superposition of experimental (black traces) and simulated currents (red traces). Currents were elicited by depolarizations to membrane potentials ranging from −10 to 90 mV in 20-mV increments. The inset displays the onset of currents in an expanded timescale. (B) Individual model current contributions attributed to channel A (blue traces) and channel B (green traces). For every voltage, the currents in A are the sum of the traces in B. The inset displays the currents predicted for channels A and B in an expanded timescale. (C) Voltage dependence of peak IKV from experimental data (circles) and from currents predicted for channels A (blue trace) and B (green trace). The black trace is the sum of the currents from channels A and B. (D) Voltage dependence of peak gKV for the experimental currents (circles) and for the currents thought to be A (blue trace) and B channels (green trace). The black trace was the predicted conductance from the overall model simulations. The model parameters for this particular fiber are listed in Table 2 (see Appendix for nomenclature).
