Figure 2.

Structure of a TRPV1-CT peptide in complex with Ca2+–CaM. (A) Ribbon diagrams of TRPV1-CT35 (cyan) bound to Ca2+–CaM, shown in two different orientations; the view on the right is rotated 70° around the vertical axis with respect to the one on the left. The CaM N-lobes and C-lobes are yellow and orange, respectively, and the calcium ions are gray. (B) Stereoview of TRPV1-CT35 (stick representation; residues 785–797) bound to Ca2+–CaM (gray ribbons with dark gray Ca2+ ion spheres). The 2Fo–Fc electron density map corresponding to TRPV1-CT35 is shown in cyan, contoured at 1.0 σ. (C) Stereoview of TRPV1-CT35 in stick representation with the corresponding 2Fo–Fc electron density map contoured at 1.0 σ (cyan). Several key residues are labeled.

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