Features of measured and modeled WT hEAG1 current during test pulses to +30 mV. (A–H) Plots of normalized maximum (I_max) and end (I_end) currents during test pulse for control (A and B) in the presence of 2 (C and D), 5 (E and F), and 10 µM ICA (G and H). In each panel, experimentally measured currents (curves) are compared with modeled currents (X), all normalized to their respective I_max.