Figure 2.
Figure 2. Parameters of TAA block of RyR2 channels. (A) Rates of TAA association (closed circles, kon) and dissociation (open circles, koff) were determined at 60 mV and are plotted against cation hydrophobicity (monitored as the octanol/water partition coefficient). (B) The residual current after the interaction of 200 µM TBA, 100 µM TPeA, and 10 µM THexA was determined at 60 mV and expressed as a percentage of full open current and is plotted against the radius of gyration of the three TAAs (determined using SYBYL; Tripos). (A and B) Data are plotted as mean values (±SEM; n = 4 for TBA and THexA and n = 5 for TPeA).

Parameters of TAA block of RyR2 channels. (A) Rates of TAA association (closed circles, kon) and dissociation (open circles, koff) were determined at 60 mV and are plotted against cation hydrophobicity (monitored as the octanol/water partition coefficient). (B) The residual current after the interaction of 200 µM TBA, 100 µM TPeA, and 10 µM THexA was determined at 60 mV and expressed as a percentage of full open current and is plotted against the radius of gyration of the three TAAs (determined using SYBYL; Tripos). (A and B) Data are plotted as mean values (±SEM; n = 4 for TBA and THexA and n = 5 for TPeA).

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