Ion channels that may be involved in sensing noxious heat. Like TRPV1 and ANO1, TRPM3 is activated by painfully hot stimuli. Inhibition of two-pore potassium leak channels (K2P) may also play a role on nociceptor signaling. Reprinted by permission from Macmillan Publishers, Ltd. Nature Neuroscience. 15:931–933. 2012.

Ion channels that may be involved in sensing noxious heat. Like TRPV1 and ANO1, TRPM3 is activated by painfully hot stimuli. Inhibition of two-pore potassium leak channels (K2P) may also play a role on nociceptor signaling. Reprinted by permission from Macmillan Publishers, Ltd. Nature Neuroscience. 15:931–933. 2012.

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