Distribution of ordered waters in a chimeric form of the human A2A adenosine receptor in complex with a high affinity antagonist. The high resolution structure is shown in light blue, waters are represented as red spheres, and the sodium ion is represented as a blue sphere. The almost-continuous water channel containing three major water clusters is depicted in gray. From Liu et al., 2012. Science. 337:232–236. Reprinted with permission from AAAS.

Distribution of ordered waters in a chimeric form of the human A2A adenosine receptor in complex with a high affinity antagonist. The high resolution structure is shown in light blue, waters are represented as red spheres, and the sodium ion is represented as a blue sphere. The almost-continuous water channel containing three major water clusters is depicted in gray. From Liu et al., 2012. Science. 337:232–236. Reprinted with permission from AAAS.

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