Morphological control to restore mitochondrial function in metabolic insult. Proper maintenance of mitochondrial morphology ensures proper bioenergetic activities and vice versa. Because of a reciprocal relationship between mitochondrial form and function, dysregulation of either mitochondrial morphology or function in metabolic excess causes a cycle of mitochondrial dysfunction and deformation, resulting in metabolic disease. Morphological intervention could put the brake on this vicious cycle and restore normal form of mitochondria, which leads to the recovery of normal function.