Figure 7.
![Figure 7. The mean open time of W401F-CFTR is [ATP] dependent. (A) Microscopic current traces of W401F-CFTR in the presence of 10 mM (top), 1 mM (middle), or 100 µM (bottom) ATP. (B) Mean open time of W401F-CFTR at different [ATP] (closed circles). *, P < 0.05 when compared with 10 mM [ATP]. (C) Macroscopic current of W401F-CFTR was activated by 10 mM ATP to a steady state. The current relaxation upon ATP washout was fitted with a single-exponential function (red curve). τ = 389 ± 13 ms (n = 8).](https://cdn.rupress.org/rup/content_public/journal/jgp/139/5/10.1085_jgp.201210789/4/jgp_201210789r_fig7.jpeg?Expires=1773486127&Signature=h~G-8NA~08tmGbt30tFiSSrLNL3pWRSuK~CfwndJe5lytuBs2ADj1lt4shyhzC6zpDYfFe1wkNPNFH5bQ9OWGxU4lwgU7yU46DSV4rjL4ahYWOFWFDMmXmOYSeuTip8v0dNo~6z6P5-~KzGYuW1HciTLPbNowE8Pt9YYQV0mhFZRVK0EJ--JsiHAKwkXQhFJC-PhKTe9P4VqgrRBivecxKY5cXhfuL8ETs~AXW4oWIVRIJsG-4-x3ogX4ymniF4iIEpm~6xT1d-gzvgHW4nbBUrZCD-2tg1Z0tsjAMSq85WZwk0mLv02Ry~D644TgKIA3VJsngsvkNcPm2KD51Ba1A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The mean open time of W401F-CFTR is [ATP] dependent. (A) Microscopic current traces of W401F-CFTR in the presence of 10 mM (top), 1 mM (middle), or 100 µM (bottom) ATP. (B) Mean open time of W401F-CFTR at different [ATP] (closed circles). *, P < 0.05 when compared with 10 mM [ATP]. (C) Macroscopic current of W401F-CFTR was activated by 10 mM ATP to a steady state. The current relaxation upon ATP washout was fitted with a single-exponential function (red curve). τ = 389 ± 13 ms (n = 8).
