Figure 4. Interval duration histograms and example currents at different membrane potentials. (A) Diliganded gating activated by 50 µM Cho (the construct was αA96L + δV269A). (B) Unliganded gating (no agonist in the pipette or bath; the construct was αA96Y + δV269A). The extra components in the interval duration histograms in unliganded gating are not apparent in diliganded gating. Both with and without agonists, the shut lifetime decreases and the open lifetime increases with hyperpolarization.
Figure 4.

Interval duration histograms and example currents at different membrane potentials. (A) Diliganded gating activated by 50 µM Cho (the construct was αA96L + δV269A). (B) Unliganded gating (no agonist in the pipette or bath; the construct was αA96Y + δV269A). The extra components in the interval duration histograms in unliganded gating are not apparent in diliganded gating. Both with and without agonists, the shut lifetime decreases and the open lifetime increases with hyperpolarization.

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