![Figure 10. Kinetic model for permeation through Kir1.1 channels. (A) Kinetic scheme with six ion-binding sites and five states. (B) Fits of i-V relationships with symmetrical [K+]. (C) Fits of i-V relationships with symmetrical [NH4+]. (D) Fits of i-V relationships with fixed internal [K+] and variable external [NH4+]. (E) Saturation of K+ and NH4+ currents in the simulated channel. (F) Energy profile for K+ and NH4+ movement through the pore of Kir1.1. The major differences are in the well depths of S1 and S2.](https://cdn.rupress.org/rup/content_public/journal/jgp/139/2/10.1085_jgp.201110727/4/jgp_201110727_fig10.jpeg?Expires=1767676451&Signature=jVnUQ4aIts78HNBjYpwJlwCou9muBmmAx7fobrBXgkscMxX8vShowjZG6zxHYFvoA5jJ-rUBrvb7fFlKXspa9~KLZYE47mUdWPKGO8OPA0aNh5fC0Gx4mWvY0Dtr0nqfLK~sms0ZBzAB~pnWtvYO6Dx0fnX8h8dAMI8YP9Uqp6b1188rgAFlo6pxGaiVjvk4OsW6oSaUp8TjOcfnZbZ0y09XuQ1LZa2J4y0ZrOnr7M8rdpFv52pagIVj37P2YJ~UlZSTfxGf~7~lBPGuGsVEUBIKyCKoLyryLVnr3oXOAULB~ObMnpskx4jbZCeXsqZZD06bCSefbG7R0xENXdZMbw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 10.
Kinetic model for permeation through Kir1.1 channels. (A) Kinetic scheme with six ion-binding sites and five states. (B) Fits of i-V relationships with symmetrical [K+]. (C) Fits of i-V relationships with symmetrical [NH4+]. (D) Fits of i-V relationships with fixed internal [K+] and variable external [NH4+]. (E) Saturation of K+ and NH4+ currents in the simulated channel. (F) Energy profile for K+ and NH4+ movement through the pore of Kir1.1. The major differences are in the well depths of S1 and S2.
