Figure 8.
![Figure 8. Simulated response to a 1-min stimulation with various concentrations of BzATP. Gray bars indicate the various concentrations of BzATP. (A) Fraction of receptors in the two closed states, C1 (black) and C4 (gray). (B) Fraction of receptors in open states, Q1 + Q2 (black), and dilated states, Q3 + Q4 (gray). Free BzATP in each stimulation was identical. As in Fig. 7 C, this was achieved by variable BzATP and [Ca2+]e (identified by the [DC]e values, top row). Increased [Ca2+]e increases the allosteric inhibition of P2X7R and thus reduces receptor sensitization and pore dilation (i.e., leads to a shift to the bottom row of Fig. S2).](https://cdn.rupress.org/rup/content_public/journal/jgp/138/4/10.1085_jgp.201110647/4/jgp_201110647_gs_fig8.jpeg?Expires=1767745281&Signature=Oiu6HGvcL2~avHe5~ifte4mJGf6WosXc1G~YaUHKsPwimlhw4X-JztnsZ2csd6eiIA9~35GSQiAWx0DIbWYc8uSBbVs4phjD2wuBPAwGAL7WxQjYoE8RLALcRR--4vQO5MCtVgRNbtjtoIDuVlyzwcLCAe5~XWt3~KYCsYc9DtdkcOdsufwXlm6MK0tDlk6CxnJSydpijkrQG-W5b87WCRFUaytuHwUKs5qBpUFKelvtT6TExepqQK7M4WOkPgIBF7NZISt8dc9Uy~Du69j8dCP8PYYwHiyECW4Ko2UkNiGHNBJP~ep1PBnl8gOlx77xLhfePUFfGMykAewciIjg4Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Simulated response to a 1-min stimulation with various concentrations of BzATP. Gray bars indicate the various concentrations of BzATP. (A) Fraction of receptors in the two closed states, C1 (black) and C4 (gray). (B) Fraction of receptors in open states, Q1 + Q2 (black), and dilated states, Q3 + Q4 (gray). Free BzATP in each stimulation was identical. As in Fig. 7 C, this was achieved by variable BzATP and [Ca2+]e (identified by the [DC]e values, top row). Increased [Ca2+]e increases the allosteric inhibition of P2X7R and thus reduces receptor sensitization and pore dilation (i.e., leads to a shift to the bottom row of Fig. S2).
