Figure 6.
Figure 6. Alignment of Kv channels and energetics of mode shift. (A) Mode shift of the charge movement in ShakerIR and ShakerIR-W434F and relationship with the energies of pore opening and closing. (B) Alignment of the S4-S5 linker and C-terminal S6 region of human Kv channels. I384, F481, and F484 are highlighted.

Alignment of Kv channels and energetics of mode shift. (A) Mode shift of the charge movement in ShakerIR and ShakerIR-W434F and relationship with the energies of pore opening and closing. (B) Alignment of the S4-S5 linker and C-terminal S6 region of human Kv channels. I384, F481, and F484 are highlighted.

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