Piezo1 and Piezo2 are candidate mechanotransduction molecules. (A) Predicted hydropathy plots for Piezo1 and Piezo2 proteins. The plot displays putative transmembrane (red), intracellular (black), and extracellular (gray) domains, as predicted by the TMHMM 2.0 server. (B) Mechanically activated currents in HEK293T cells expressing Piezo1 (FAM38A; left) or Piezo2 (FAM38B; right). Representative inward currents in response to a series of 1-µm mechanical steps applied via a glass probe. Whole cell recordings performed at −80 mV. B is modified with permission from Coste et al. (2010).