Recovery of inhibited channels bypasses the reopening step. (A) A continuous current trace of E1371S/ΔR-CFTR channels showing that some of the inhibited channels recover from inhibition without reopening. Similar observations were made in seven patches containing two to four channels. (B) Faster recovery of inhibited E1371S/ΔR-CFTR channels in the absence of ATP. 2 min after the removal of CFTRinh-172, more current can be elicited by ATP than that with ATP in the washout solution (Fig. 6 C).