Figure 1.
![Figure 1. Simulation of the influence of the energy profile along the pore on Na+ and K+ permeation through an ion channel. (A) Simulated energy profile along a pore for Na+ and K+ ions. (B) I-V curves for such a channel, in control (solid line) or decreased [Cl−]o (left dashed line) or [Cl–]i (right dashed line). (C and D) The energy profile (C) and the integral of the energetic barrier (D) in the presence of −75 mV membrane potential (middle) and possible effects of decreased Cl− concentration on the outer (left) or inner side (right) of the membrane.](https://cdn.rupress.org/rup/content_public/journal/jgp/138/3/10.1085_jgp.201110690/4/jgp_201110690_lw_fig1.jpeg?Expires=1769205000&Signature=M~tRSZGQrdrAYjY~5VcK9TeIbLqdQfvwtdLWyjiQP2GMc3AA6fvPtGLoc5AsD41Hpm613T5DTQDE7PWammUJgsbCN-S5kDHu9sML0TLfpAiltqzNvhcBduPJqzPPUOGm7B72Pj8Z8VLblz56aqJfYZt6GakP5jfynWOgPzAjLRx8QDt78mk~Tvjpb-RpMp1nqYGQnCGdPJH3dAZKslqozdtZLkkLtTCBCmZE6yhY3TWXz9MKW-xMW80nzCA~ADJ67p78LE7HpsirZNGot0ohZhMkcc70Z27jm5pnVJyxwnBNbDkokkubboElB92vftIy9NWmsVQ9OMQb48cPn84O9A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Simulation of the influence of the energy profile along the pore on Na+ and K+ permeation through an ion channel. (A) Simulated energy profile along a pore for Na+ and K+ ions. (B) I-V curves for such a channel, in control (solid line) or decreased [Cl−]o (left dashed line) or [Cl–]i (right dashed line). (C and D) The energy profile (C) and the integral of the energetic barrier (D) in the presence of −75 mV membrane potential (middle) and possible effects of decreased Cl− concentration on the outer (left) or inner side (right) of the membrane.
