Figure 5.
Figure 5. Summary for ICa,pre amplitude and SV pool sizes before and after HFS (40 s) under different presynaptic conditions. (A) Baseline amplitudes of ICa,pre and RRP sizes estimated before HFS are compared between different presynaptic conditions: addition of DMSO (DMSO), 3 µM CaM (CaM), CaM plus 100 µM blebbistatin (Bleb), CaM plus 10 µM MLCK inhibitor peptide-18 (Mip) or CaM plus 3 µM wortmannin (WMN) to the presynaptic patch pipette. Mean values for the amplitude of ICa,pre (a), the FRP size (b), the SRP size (c), and the total RRP size (d) are shown as bar graphs. (B) Ratios of the same parameters as shown in A at 40 s after HFS (PTP) to those before HFS (Ctrl). Mean values for ratio of the amplitudes of ICa,pre (a), the FRP size (b), the SRP size (c), and the total RRP size (d) are shown. Mean ± SEM, * P < 0.05; ** P < 0.01 (unpaired t test).

Summary for ICa,pre amplitude and SV pool sizes before and after HFS (40 s) under different presynaptic conditions. (A) Baseline amplitudes of ICa,pre and RRP sizes estimated before HFS are compared between different presynaptic conditions: addition of DMSO (DMSO), 3 µM CaM (CaM), CaM plus 100 µM blebbistatin (Bleb), CaM plus 10 µM MLCK inhibitor peptide-18 (Mip) or CaM plus 3 µM wortmannin (WMN) to the presynaptic patch pipette. Mean values for the amplitude of ICa,pre (a), the FRP size (b), the SRP size (c), and the total RRP size (d) are shown as bar graphs. (B) Ratios of the same parameters as shown in A at 40 s after HFS (PTP) to those before HFS (Ctrl). Mean values for ratio of the amplitudes of ICa,pre (a), the FRP size (b), the SRP size (c), and the total RRP size (d) are shown. Mean ± SEM, * P < 0.05; ** P < 0.01 (unpaired t test).

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