Figure 12.
Figure 12. Averaged and normalized Ig of WT hERG1 channels measured using p/−8 leak and capacitance current subtraction. (A) Ig in response to test voltages Vt of −60, −30, …+60 mV during 0–300 ms. The membrane voltage is clamped to −110 mV otherwise. (B and C) IgON at 0–10 ms and 10–300 ms, respectively. (D and E) IgOFF at 300–310 ms and 310–600 ms, respectively.

Averaged and normalized Ig of WT hERG1 channels measured using p/−8 leak and capacitance current subtraction. (A) Ig in response to test voltages Vt of −60, −30, …+60 mV during 0–300 ms. The membrane voltage is clamped to −110 mV otherwise. (B and C) IgON at 0–10 ms and 10–300 ms, respectively. (D and E) IgOFF at 300–310 ms and 310–600 ms, respectively.

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