Cd²⁺ reduces the fast and slow components of Ig_ON and induces the appearance of I_Cd-out, a brief initial outward component that precedes Ig_OFF. (A) Superimposed traces for gating currents measured before and after treatment of an oocyte with 30 µM Cd²⁺. Top panel shows pulse protocol. (B) Ig_ON shown on an expanded time scale. (C) Ig_OFF shown on an expanded time scale.