![Figure 3. Effects of PKA treatment on Ca2+ sensitivity of force in WT, cTnIAla5, cMyBP-C−/−, and cTnIAla5/cMyBP-C−/− skinned myocardium. Relative isometric steady-state force (P/P0) measured as a function of −log [Ca2+]free (pCa) in untreated (•; n = 8) and PKA-treated (○; n = 8) preparations. Smooth lines were generated by fitting the mean data to a Hill equation, as described in Materials and methods. All data are plotted as means ± SEM.](https://cdn.rupress.org/rup/content_public/journal/jgp/136/6/10.1085_jgp.201010448/5/jgp_201010448_lw_fig3.jpeg?Expires=1767669778&Signature=CmAFVdGqDHG0dH~RprjI044O0RmOmSnhPze81SckUtXghFB86s0LBjUYaVM~j4-EPY2nFvIGp6NE907HTj-qN338idGd698LyPfikwnMbl6ngTVPKRZ-Y4ht0AJOELPW72liQI7CDrV~ZSjzWrcWfZrmf2GZ8s6Ri2obEmcTvgN9OmH-x1777JlyDA-nm0ubMdy1KUcYo1pO1~PoZ9oGNGtUoNyTqqw~wGHyXeXgm7yP20SA0kqZWuBAYjjUk1h2F67YIkWJ6HlCbyZitCI7ns-EsW1vaOZhGlj~PuoJONXwaKptxY0qglvKb4~7sf9dwvvp0ob6dgw-MDWF4vPVIA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 3.
Effects of PKA treatment on Ca2+ sensitivity of force in WT, cTnIAla5, cMyBP-C−/−, and cTnIAla5/cMyBP-C−/− skinned myocardium. Relative isometric steady-state force (P/P0) measured as a function of −log [Ca2+]free (pCa) in untreated (•; n = 8) and PKA-treated (○; n = 8) preparations. Smooth lines were generated by fitting the mean data to a Hill equation, as described in Materials and methods. All data are plotted as means ± SEM.
