Figure 2.
Figure 2. PKA inhibition reduces β adrenergic regulation of If in sinoatrial myocytes. (A and B) Conductance–voltage relationships for If determined in control intracellular solution (A) or intracellular containing 10 µM PKI (B) in the absence (closed black or gray symbols) and presence (open red or blue symbols) of 1 µM isoproterenol. (A, inset) Representative currents elicited by 3-s hyperpolarizing voltage steps from −60 to −170 mV in 10-mV increments. Scale bars in the inset are 500 pA and 200 ms. (C) Average activation midpoints for If in different conditions, as indicated. Isoproterenol significantly shifted the voltage dependence for If in the absence of PKI (asterisk, P < 0.05), but not in the presence of PKI (NS, not significant).

PKA inhibition reduces β adrenergic regulation of If in sinoatrial myocytes. (A and B) Conductance–voltage relationships for If determined in control intracellular solution (A) or intracellular containing 10 µM PKI (B) in the absence (closed black or gray symbols) and presence (open red or blue symbols) of 1 µM isoproterenol. (A, inset) Representative currents elicited by 3-s hyperpolarizing voltage steps from −60 to −170 mV in 10-mV increments. Scale bars in the inset are 500 pA and 200 ms. (C) Average activation midpoints for If in different conditions, as indicated. Isoproterenol significantly shifted the voltage dependence for If in the absence of PKI (asterisk, P < 0.05), but not in the presence of PKI (NS, not significant).

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