Figure 1.
Figure 1. PKA activity contributes to β adrenergic regulation of If in sinoatrial myocytes. (A and C) Representative whole cell If currents recorded from isolated sinoatrial myocytes in the whole cell patch clamp configuration. Currents were elicited by voltage steps to −120 mV from a holding potential of −50 mV in the absence (black) or presence (red or blue) of 1 µM isoproterenol (ISO) applied in the extracellular Tyrode’s solution. Traces in A were recorded with a control intracellular solution, traces in C were recorded with intracellular solution containing 10 µM PKI. (B and D) Time course of the ISO-dependent increase in If for the cells shown in A and C. The open and colored bars indicate the composition of the extracellular perfusing solution. Black, red, and blue circles mark the traces shown in A and C.

PKA activity contributes to β adrenergic regulation of If in sinoatrial myocytes. (A and C) Representative whole cell If currents recorded from isolated sinoatrial myocytes in the whole cell patch clamp configuration. Currents were elicited by voltage steps to −120 mV from a holding potential of −50 mV in the absence (black) or presence (red or blue) of 1 µM isoproterenol (ISO) applied in the extracellular Tyrode’s solution. Traces in A were recorded with a control intracellular solution, traces in C were recorded with intracellular solution containing 10 µM PKI. (B and D) Time course of the ISO-dependent increase in If for the cells shown in A and C. The open and colored bars indicate the composition of the extracellular perfusing solution. Black, red, and blue circles mark the traces shown in A and C.

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