Figure 4. Use-dependent block of WT and mutant channels by lidocaine. (A) Representative ionic current traces of WT channel in the presence of different concentrations of lidocaine. Each trace was obtained by applying 100 pulses from −80 to −20 mV for 20 ms at 10 Hz from a holding potential of −80 mV. (B) Dose–response curve for use-dependent block of WT channel by lidocaine. The symbols represent mean ± SEM of at least three independent measurements, and the smooth line represents the best fit of the averaged data to the Hill equation. (C) Percent block of WT and mutant channels after 100 pulses in presence of 1 mM lidocaine. Gray dashed line represents the mean percent block of the WT channel (71.5 ± 2.2%; n = 5). The current protocol is the same as in A. In both B and C, the data represent mean ± SEM of at least three independent measurements.
Figure 4.

Use-dependent block of WT and mutant channels by lidocaine. (A) Representative ionic current traces of WT channel in the presence of different concentrations of lidocaine. Each trace was obtained by applying 100 pulses from −80 to −20 mV for 20 ms at 10 Hz from a holding potential of −80 mV. (B) Dose–response curve for use-dependent block of WT channel by lidocaine. The symbols represent mean ± SEM of at least three independent measurements, and the smooth line represents the best fit of the averaged data to the Hill equation. (C) Percent block of WT and mutant channels after 100 pulses in presence of 1 mM lidocaine. Gray dashed line represents the mean percent block of the WT channel (71.5 ± 2.2%; n = 5). The current protocol is the same as in A. In both B and C, the data represent mean ± SEM of at least three independent measurements.

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