Figure 1. Sequence alignment of the putative transmembrane segments of domain III of the brain, nerve, and the muscle sodium channels (Nav1.2, Nav1.4, and Nav1.5) with a chimeric potassium channel (Kv1.2/2.1). The conserved positive charges of the S4 transmembrane segment are highlighted in green. The mutated regions in the S4–S5 linker, N terminus of S5, and C terminus of S6 are shown in red. The fluorophore was attached to an introduced cysteine at the L1115C (in orange) position.
Figure 1.

Sequence alignment of the putative transmembrane segments of domain III of the brain, nerve, and the muscle sodium channels (Nav1.2, Nav1.4, and Nav1.5) with a chimeric potassium channel (Kv1.2/2.1). The conserved positive charges of the S4 transmembrane segment are highlighted in green. The mutated regions in the S4–S5 linker, N terminus of S5, and C terminus of S6 are shown in red. The fluorophore was attached to an introduced cysteine at the L1115C (in orange) position.

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