Potentiation of GluK2(Q) L614R and L614K associated with a positive shift in reversal potential. Whole-cell currents elicited by 10 µM kainate between −100 and +100 mV as the membrane potential was ramped at ∼1 mV/ms; internal cesium glucuronate. (A) Kainate-evoked current mediated by GluK2(Q) L614R before (black) and after (red) exposure to DHA using external NaCl. Following recovery from DHA potentiation, kainate-evoked current was recorded using extracellular sodium glucuronate (blue). (B) Similar experiment for GluK2(Q) L614K.