Figure 4. I-V relationships of various mutants generating constitutive current (left). Protocol same as Fig. 1 B. (Right) Block of current by KCNQ1 pore blocker chromanol 293B (100 µM) while pulsing to +40 mV for 5 s, repolarizing at −40 mV for 3 s, and holding at −80 mV for 32 s.
Figure 4.

I-V relationships of various mutants generating constitutive current (left). Protocol same as Fig. 1 B. (Right) Block of current by KCNQ1 pore blocker chromanol 293B (100 µM) while pulsing to +40 mV for 5 s, repolarizing at −40 mV for 3 s, and holding at −80 mV for 32 s.

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