Figure 4.
Figure 4. IKs deactivation tail currents and time constants of S3 KCNQ1 mutants. (A) Deactivation of WT or mutant KCNQ1+KCNE1 ionic currents was recorded at 35°C during repolarization to potentials between −40 and −100 mV in 10-mV increments after 3-s depolarizing pulses to +80 mV. (B) Time constants (τdeact) were from single-exponential fits to tail currents and are plotted versus membrane potential (WT, n = 25; D202H, n = 5; V205M, n = 7; I204F, n = 8; S209F, n = 10; V215M, n = 7–11).

IKs deactivation tail currents and time constants of S3 KCNQ1 mutants. (A) Deactivation of WT or mutant KCNQ1+KCNE1 ionic currents was recorded at 35°C during repolarization to potentials between −40 and −100 mV in 10-mV increments after 3-s depolarizing pulses to +80 mV. (B) Time constants (τdeact) were from single-exponential fits to tail currents and are plotted versus membrane potential (WT, n = 25; D202H, n = 5; V205M, n = 7; I204F, n = 8; S209F, n = 10; V215M, n = 7–11).

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