Figure 3.
Figure 3. IKs current density and detailed activation kinetics of S3 domain KCNQ1 mutants. (A) Current densities for WT and mutant KCNQ1+KCNE1-transfected cells at each potential. (B) Activation time constants (τact) from fits to currents in Fig. 2 at each potential (WT, n = 17; D202H, n = 7; V205M, n = 7; I204F, n = 8; S209F, n = 8; V215M, n = 7–11). (C) g-V relationships from the peak tail currents. In all cases, measurements were made from currents recorded using the protocols described in the legend to Fig. 2.

IKs current density and detailed activation kinetics of S3 domain KCNQ1 mutants. (A) Current densities for WT and mutant KCNQ1+KCNE1-transfected cells at each potential. (B) Activation time constants (τact) from fits to currents in Fig. 2 at each potential (WT, n = 17; D202H, n = 7; V205M, n = 7; I204F, n = 8; S209F, n = 8; V215M, n = 7–11). (C) g-V relationships from the peak tail currents. In all cases, measurements were made from currents recorded using the protocols described in the legend to Fig. 2.

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