Figure 2. IKs current traces for WT and S3 KCNQ1 mutants. WT KCNQ1+KCNE1 or mutant KCNQ1+KCNE1 ionic currents were recorded at 35°C during 2-s depolarizing pulses to between −100 and +100 mV, followed by a 1-s repolarizing pulse to −50 mV. Cartoon is of KCNQ1 in the open state, with residues in which mutations have been identified in S3 represented in space fill. Only one subunit is shown, except for the filter and pore helix of an adjacent subunit for orientation purposes. The color scheme is as follows: yellow, S1; green, S2; salmon, S3; magenta, S4; the rest of the subunit is gray.
Figure 2.

IKs current traces for WT and S3 KCNQ1 mutants. WT KCNQ1+KCNE1 or mutant KCNQ1+KCNE1 ionic currents were recorded at 35°C during 2-s depolarizing pulses to between −100 and +100 mV, followed by a 1-s repolarizing pulse to −50 mV. Cartoon is of KCNQ1 in the open state, with residues in which mutations have been identified in S3 represented in space fill. Only one subunit is shown, except for the filter and pore helix of an adjacent subunit for orientation purposes. The color scheme is as follows: yellow, S1; green, S2; salmon, S3; magenta, S4; the rest of the subunit is gray.

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