Figure 10.
A kinetic model simulates exocytosis. (A) Cartoon of the vesicle pools and transitions assumed in the model. (B) Formal kinetic diagram corresponding to cartoon in A and showing the stimulus conditions that affect each step. (C) Comparison of simulated time courses of the rate of exocytosis (blue lines) with recorded data from previous figures (filled circles). The left column is without and the right column with FSK treatment under five different stimuli. (C, a and b) Exocytosis evoked by ionomycin-mediated Ca2+ (same data as in Fig. 2 B). (C, c–h) Exocytosis induced by different concentrations of UTP (from Fig. 4). (C, i–j) Exocytosis triggered by 100 nM trypsin (from Fig. 3 D).
