Figure 12. Molecular model of CFTR gating. (A) A simplified diagram illustrating dominant gating transitions (C2↔O) and a second gating cycle (C1→C2’→O→C2→C1) involving complete disengagement of the two NBDs. (B) A proposed mechanism for partial separation and reformation of the NBD dimer. Cubes, head subdomains of NBDs; pyramids, tail subdomains of NBDs.
Figure 12.

Molecular model of CFTR gating. (A) A simplified diagram illustrating dominant gating transitions (C2↔O) and a second gating cycle (C1→C2’→O→C2→C1) involving complete disengagement of the two NBDs. (B) A proposed mechanism for partial separation and reformation of the NBD dimer. Cubes, head subdomains of NBDs; pyramids, tail subdomains of NBDs.

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