Figure 5. Dose–response curves for spermine block of unmodified and MTSEA- or MTSET-modified channel constructs. Spermine blockade was measured over a range of voltages and concentrations in unmodified and MTSEA- or MTSET-modified (A) Kir2.1*-169C or (B) Kir2.1*-176C channels. Solid lines represent simultaneous fitting of data from all spermine concentrations and voltages to the model described by Scheme 1.
Figure 5.

Dose–response curves for spermine block of unmodified and MTSEA- or MTSET-modified channel constructs. Spermine blockade was measured over a range of voltages and concentrations in unmodified and MTSEA- or MTSET-modified (A) Kir2.1*-169C or (B) Kir2.1*-176C channels. Solid lines represent simultaneous fitting of data from all spermine concentrations and voltages to the model described by Scheme 1.

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