Figure 5.
![Figure 5. Mgi modulation of the voltage dependence of inactivation of WT CaV1.2 and C-terminal EF-hand mutant (CaV1.2(D1546K)) with Na+ as charge carrier. Comparison of mean inactivation–voltage relationships for ICaV1.2(Na) of WT CaV1.2 (A) and C-terminal EF-hand mutant (D1546K) (B) exposed to the indicated Mgi. (C) Plot of fraction Inon-inact versus log [Mgi] for WT CaV1.2 and C-terminal EF-hand mutant (D1546K). Curves represent the best fit of a binding isotherm to the data, with KD = 0.78 ± 0.04 mM for WT and KD = 3.6 ± 1.4 mM Mgi for D1546K.](https://cdn.rupress.org/rup/content_public/journal/jgp/134/2/10.1085_jgp.200910209/4/jgp_200910209_lw_fig5.jpeg?Expires=1771668972&Signature=ogbYNoGaUjlj3-3EoG7iZ2nnpye0aLgfRj5reDQU4ASXxaSjpymu37tPPl04W2GLdFi3eY4ZqkCJl3uWw0tuUnL50zBxdqJI2nB7mCUNIN47ulh7JgpfBoftycPB~Cmvn7n9bymMFjVXPGKu2Ct9tv5s2ql78tuD623vfG2RDFsm9jUaJ15BUEeeIYr-uu6BpT~j68y6GpyQh7hOFApDQ0zV0RupGJxbfS7Q0LalPfqYXSd9P~N0ZslOCETGb9E3NitFVwuVDHImUA8JRxgxVYTN6axDdnyo3jII8x4Q5mXioUsn5dyMBxX511rArMKTJTA9P008dsnGpZKOyDKf3Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Mgi modulation of the voltage dependence of inactivation of WT CaV1.2 and C-terminal EF-hand mutant (CaV1.2(D1546K)) with Na+ as charge carrier. Comparison of mean inactivation–voltage relationships for ICaV1.2(Na) of WT CaV1.2 (A) and C-terminal EF-hand mutant (D1546K) (B) exposed to the indicated Mgi. (C) Plot of fraction Inon-inact versus log [Mgi] for WT CaV1.2 and C-terminal EF-hand mutant (D1546K). Curves represent the best fit of a binding isotherm to the data, with KD = 0.78 ± 0.04 mM for WT and KD = 3.6 ± 1.4 mM Mgi for D1546K.
