Figure 9. Charge neutralization or reversal of two other basic residues in the helix A-B linker produces highly divergent effects. Shown are single-channel records at 0 mV from Kv7.2 R463Q and R467Q (A), or R463E and R467E (B), in the cell-attached (left) or inside-out configuration in the presence of 25 μM diC8-PIP2 (right). (C) Bars show summarized Po values at 0 mV for both configurations for the indicated mutant. Asterisks above each bar indicate the level of significance compared with the corresponding values for Kv7.2 wt. **, P < 0.01; ***, P < 0.001.
Figure 9.

Charge neutralization or reversal of two other basic residues in the helix A-B linker produces highly divergent effects. Shown are single-channel records at 0 mV from Kv7.2 R463Q and R467Q (A), or R463E and R467E (B), in the cell-attached (left) or inside-out configuration in the presence of 25 μM diC8-PIP2 (right). (C) Bars show summarized Po values at 0 mV for both configurations for the indicated mutant. Asterisks above each bar indicate the level of significance compared with the corresponding values for Kv7.2 wt. **, P < 0.01; ***, P < 0.001.

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