Figure 7. The Kv7.2 KRR-EEE mutant displays reduced apparent affinity and efficacy of diC8-PIP2 for channel opening. (A) Shown are single-channel records at 0 mV from wt (left) and KRR-EEE (right) Kv7.2 channels in inside-out patches under the indicated concentrations of diC8-PIP2. (B) Plotted are the summarized values of the Po at 0 mV for the two channels versus diC8-PIP2 concentration. The data were fit by Hill equations of the form and parameters given in the text.
Figure 7.

The Kv7.2 KRR-EEE mutant displays reduced apparent affinity and efficacy of diC8-PIP2 for channel opening. (A) Shown are single-channel records at 0 mV from wt (left) and KRR-EEE (right) Kv7.2 channels in inside-out patches under the indicated concentrations of diC8-PIP2. (B) Plotted are the summarized values of the Po at 0 mV for the two channels versus diC8-PIP2 concentration. The data were fit by Hill equations of the form and parameters given in the text.

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