Simulated single-channel data and closed dwell-time distributions for the three-state model described by Scheme 2. (A) Simulated single-channel current record. Channel openings are shown as upward steps. (B) Sigworth and Sine plot of the closed-dwell time distribution for 10⁶ simulated intervals. (C) Same data as in B on linear coordinates. The dashed lines in both plots indicate the fast E₁ and slow E₂ exponential components. The time constants (arrows) and areas, which are identical in both B and C, are listed.