Microglial reprogramming by AIBP is dependent on ABCA1/ABCG1 expression. (A) Venn diagram comparing the effect of AIBP treatment on gene expression in WT and ABC-imKO mice in which CIPN was induced by cisplatin. (B) Volcano plot representation of up- and down-regulated genes by AIBP treatment in CIPN comparing AIBP effect on ABC-imKO versus WT mice. Cutoff of adjusted P < 0.05 and absolute fold change >1.5 shown in light green dots. (C) Heatmap of log₂ normalized gene counts of inflammatory genes altered by AIBP in an ABC-dependent manner (down-regulated by AIBP in WT microglia but up-regulated by AIBP in ABC-imKO. (D) Heatmap of cholesterol synthesis and LXR-related genes comparing cisplatin and AIBP effect in WT and ABC-imKO. (E) Heatmap of noninflammatory genes regulated by AIBP in an ABC-dependent manner. (F) Enrichment pathway analysis of up-regulated genes by AIBP in ABC-imKO microglia, using cutoff P < 0.05, enrichment >1.5, and a minimum overlap of three genes in the pathway. Black arrows highlight cholesterol-related pathways and signaling pathway related to neurotransmitter regulation. cisp, cisplatin.