CXCL4 can be associated with DNA in vivo during inflammatory responses in the skin. (A and B) Skin injury was induced by tape stripping in WT mice, followed 1 h later by an intradermal injection of CXCL4 or PBS. Mice were sacrificed 6 h after the injection. (A) Representative images of CXCL4 expression in the skin of WT mice (Shave), Tape + PBS mice, and Tape + CXCL4 mice (n = 6–7 per group). All scale bars are 10 μm. (B) The expression of ISGs in the skin of Shave, Tape + PBS, and Tape + CXCL4 mice.