Consideration of SABV refers to the consideration and reporting of the sex of participants, animals, and hosts from which primary cell cultures are derived. The study of sex differences (sex diffs) refers to the rigorous experimentation associated with mechanistically and statistically comparing biological outcome data between males (green) and females (purple), with manipulation of the causes of these sex differences where possible (e.g., in animal and primary cell culture studies). Image generated using Biorender.