Reduced T cell–dependent antibody production in SFR KO mice. Related to Fig. 2. (A) Anti-dsDNA antibody titers were measured in nonimmunized mice. The mice are same as those in Fig. 2 A (WT, n = 9; SFR KO, n = 9). Data are from one experiment. (B) Same as Fig. 2, B and C, except that anti-NP IgG2b, IgG2c, IgG3, and IgE were measured (WT, n = 25; SFR KO, n = 23; SAP KO, n = 10; SFR SAP dKO, n = 11). Data are pooled from four experiments. Each symbol represents one mouse. *, P < 0.05; **, P < 0.01 (two-tailed Student’s t test). Data are shown as mean ± SEM. D, day; ns, not significant.