Intersection of dCLIP, RNA-seq, and TargetScan indicates 70 possible gene targets of miR-221/222 in B cells. (A–D) CDF plots comparing RNA-seq gene expression on x axis versus cumulative distribution on y axis. (A) Genes with at least one 6-mer (green), at least one 7-mer (orange), or at least one 8-mer (red) compared with those lacking an miR-221/222-3p seed site (black). (B) dCLIP predicted genes (red) compared with all others (black). (C) TargetScan predicted genes (red) compared with all others (black). (D) dCLIP and TargetScan predicted genes (red) compared with all others (black). (E) Ranked gene ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes pathways enriched in the dCLIP and TargetScan gene subset.