Potential mechanisms of translational regulation by c-Myc. c-Myc oncogene promotes mRNA translation by stimulating ribosome biogenesis, tRNA synthesis, and transcription of genes encoding translation factors. Singh et al. (2019) provide evidence suggesting that in lymphoma cells, c-Myc selectively controls translation of a subset of mRNAs which are repressed by SRSF1 and RBM42 and enriched for transcripts encoding components of ETC complexes. In addition, alterations in c-Myc levels appear to have a dramatic impact on selection of TISs, including in CD19 mRNA. This c-Myc–dependent translational reprogramming is thus anticipated to impact mitochondrial ATP production (which may help fuel translational machinery) and efficacy of immunotherapies. Future work is warranted to help consolidate these findings and, in particular, to establish the molecular underpinnings and physiological consequences of the observed phenomena. eIF, eukaryotic translation initiation factor; SRSF1, serine and arginine-rich splicing factor 1; RB42, RNA-binding motif protein 42; CD19, cluster of differentiation 19.