PROMISSE study design. (A) 92 SLE pregnant (SLE-P), 43 H-P, 20 SLE-NP, and 34 H-NP females were recruited. Pregnant SLE patients included NC (n = 46), PE (n = 24), and OC (n = 22). Blood was drawn in PAX gene tubes for microarray at specific time points (P1: <16 WG; P2: 16–23 WG; P3: 24–31 WG; P4: 32–40 WG, and between 8 and 20 wk PP). (B) Blood from 25 healthy women who underwent ART was analyzed for before and after embryo transfer by RNA-seq. Pregnancy rate for the cohort was 80% (20/25). Samples were taken on the day of the embryo transfer, midluteal, day of the pregnancy test, and P0 (4–6 WG).